The study has shown that fatty liver may be more than an indicator of obesity but may actually have an independent role in the development of Type 2 diabetes.
“Many patients and practitioners view fat in the liver as just ‘fat in the liver,’ but we believe that a diagnosis of fatty liver should raise an alarm for impending type 2 diabetes,” said senior author Sun Kim of Stanford University in California.
“Our study shows that fatty liver, as diagnosed by ultrasound, strongly predicts the development of type 2 diabetes regardless of insulin concentration,” said Kim.
For the study, researchers examined 11,091 Koreans who had a medical evaluation including fasting insulin concentration and abdominal ultrasound at baseline and had a follow-up after five years.
Regardless of baseline insulin concentration, individuals with fatty liver had significantly more metabolic abnormalities including higher glucose and triglyceride concentration and lower high-density lipoprotein cholesterol concentration.
Individuals with fatty liver also had a significantly increased risk for type 2 diabetes compare to those without fatty liver.
“Our study shows in a large population of relatively healthy individuals that identifying fatty liver by ultrasound predicts the development of type 2 diabetes in five years.
“In addition, our findings reveal a complex relationship between baseline fatty liver and fasting insulin concentration,” added Kim.
The study will be published in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism.
Article source: http://www.medindia.net/news/Fatty-Liver-May-Lead-To-Type-2-Diabetes-Risk-81469-1.htm